F5 Trunk port is connected to Cisco Switch Access Port

The wrong cabling (From the diagram above) won't cause issues because you're running LACP on the F5 trunk (Lets call it a port-channel :) ).

The LACP signalling ensures that BOTH ends of all the links in the channel connect in a single port-channel. If any of the links are NOT configured in the port-channel, then then will be shutdown by the endpoint detecting the error.

So, as long as LACP signalling is used, you shouldn't get any issues. (This assumes you're not bridging traffic across the BigIP's interfaces of course).

H